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Antigenic Specificity | MARCKS phospho S152/phospho S156 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µL |
Concentration | n/a |
Applications | Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-MARCKS pS152/pS156 antibody is directed against MARKS doubly phosphorylated at Ser152 and Ser156. MARCKS antibody are affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. The immunolabeling is completely eliminated by lambda-phosphatase. Expect reactivity with the following species based on sequence homology: bovine, chicken, human, mouse, Xenopus and zebra fish. Cross reactivity with MARCKS pS152/pS156 from other species has not been determined. MARCKS pS152/pS156 antibody detects MARKS when phosphorylated at both Ser152 and Ser156 Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is a major substrate for phosphorylation by protein kinase C (PKC). The phosphorylation of Ser152/156 can be used as a measure of PKC activation although these sites are also phosphorylated by PRK1 MARCKS is a member of a family of calmodulin binding proteins and phosphorylation of Ser 152/156 modulates the binding of MARCKS to calmodulin. Therefore, phosphorylated MARCKS antibody is ideal for investigators involved in Cell Signaling, Cell migration and Cancer Research. |
Immunogen | Anti-MARCKS pS152/pS156 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser 152/156 conjugated to KLH. |
Other Names | Myristoylated alanine-rich C-kinase substrate, Protein kinase C substrate 80 kDa protein |
Gene, Accession # | Marcks, Gene ID: 3028, UniProt: P30009 |
Catalog # | 612-401-D70 |
Price | $475 |
Order / More Info | MARCKS phospho S152/phospho S156 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |