Ubiquitin Hydrolase (UCHL1) Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Ubiquitin Hydrolase (UCHL1) |
| Clone | BH7 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat, bovine |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | ELISA, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-UCHL1 antibody is directed against human UCHL1. The antibody is protein G purified from concentrated clarified cell culture supernate. Reactivity is expected against human, bovine, mouse, and rat sources. Cross reactivity from other sources has not been determined. However, expect reactivity with UCHL1 from most mammalian sources based on sequence homology. UCHL1 antibody recognizes Ubiquitin C-terminal hydrolase 1 (UCHL1) which is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.Therefore, UCHL1 monoclonal antibody is ideal for investigators involved in Neuroscience. |
| Immunogen | Anti-UCHL1 Monoclonal Antibody was produced in mouse by repeated immunizations with recombinant full length human UCHL1 extensively purified from E. coli. |
| Other Names | mouse anti-UCHL1 Antibody, mouse anti-Ubiquitin Hydrolase Antibody, UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, Ubiquitin thioesterase L1 |
| Gene, Accession # | UCHL1, Gene ID: 7345, UniProt: P09936 |
| Catalog # | 900-301-E52 |
| Price | $485 |
| Order / More Info | Ubiquitin Hydrolase (UCHL1) Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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