BACE2 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | BACE2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-BACE2 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with BACE2 with Human, Mouse and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with BACE2 from other sources has not been determined. BACE2 antibody detects human amyloid-beta (Abeta) plaque. Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called `Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome. Anti-BACE2 antibodies are ideal for investigators involved in Neuroscience and DNA Damage and Repair. |
| Immunogen | BACE2 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to an internal region of human BACE2. |
| Other Names | AEPLC, ALP56, ASP21 |
| Gene, Accession # | BACE2, Gene ID: 25825, NCBI: NP_036237.2, UniProt: Q9Y5Z0 |
| Catalog # | 600-401-G82 |
| Price | $475 |
| Order / More Info | BACE2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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