CD4 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | CD4 |
| Clone | OKT4 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | phycoerythrin (RPE) conjugate |
| Size | 500 µL |
| Concentration | 0.012 mg/mL |
| Applications | Flow Cytometry, Immunohistochemistry, IF Microscopy, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Phycoerythrin conjugated CD4 Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against human CD4. Reactivity is observed against human CD4, Cynomolgus, Rhesus, and chimpanzee. This antibody recognizes a different epitope, and thus does not block binding of clone RPA-T4. Cross reactivity with CD4 from other sources has not been tested. Anti-CD4 is conjugated with PE under optimal conditions and the solution is free of unconjugated PE. The Anti-CD-4 antibody (OKT4) reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The OKT4 antibody is widely used as a phenotypic marker for CD4 expression. |
| Immunogen | Anti-CD4 Antibody (Monoclonal) was produced by repeated immunizations with CD4 antigen. |
| Other Names | T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD4, FITC anti-human CD4, RPA-T4, PE, T4 |
| Gene, Accession # | CD4, Gene ID: 920, NCBI: NP_000607.1, UniProt: P01730 |
| Catalog # | 200-308-N18 |
| Price | $252 |
| Order / More Info | CD4 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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