HIF-1-alpha Antibody from ROCKLAND IMMUNOCHEMICALS INC.
Search, find, compare suppliers for anti-HIF-1-alpha antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | HIF-1-alpha |
| Clone | ESEE122 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat, bovine |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-HIF1α Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with HIF1α from human, mouse, rat, and cow based on 100% homology with the immunizing sequence. Cross-reactivity with HIF1α from other sources has not been determined. Oxidative Stress/Cell Signaling research. Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response of hypoxia. The HIF1 complex consists of two subunits, HIF1-Alpha and HIF1-Beta, which are basic helix-loop-helix proteins of the PAS family. HIF1 regulates the transcription of a broad range of genes that facilitate responses to the hypoxic environment, including genes regulating angiogenesis, erythropoiesis, cell cycle, metabolism and apoptosis. The widely expressed HIF-1α is typically degraded rapidly in normoxic cells by the ubiquitin/proteasomal pathway. Under normoxic conditions, HIF-1α is proline hydroxylated leading to a conformational change that promotes binding to the von Hippel Lindau protein (VLH) E3 ligase complex; ubiquitination and proteasomal degradation follows. Both hypoxic conditions and chemical hydroxylase inhibitors (such as desferrioxamine and cobalt) inhibit HIF-1α degradation and lead to its stabilization. In addition, HIF-1α can be induced in an oxygen-independent manner by various cytokines through the PI3K-AKT-mTOR pathway. |
| Immunogen | HIF1 alpha Antibody was produced in mice by repeated immunizations raised against a recombinant fragment corresponding to an internal region of HIF1 alpha. |
| Other Names | ARNT interacting protein, HIF1A, Hypoxia inducible factor 1 alpha, MOP1, PASD8, |
| Gene, Accession # | HIF1A, Gene ID: 3091, NCBI: 4504385, UniProt: Q16665 |
| Catalog # | 200-301-F45 |
| Price | $485 |
| Order / More Info | HIF-1-alpha Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.
Return to Antibodies