Histone H3 pT3/R2-Me2s Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Histone H3 pT3/R2-Me2s |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, monkey |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 50 µg |
| Concentration | 0.21 mg/mL |
| Applications | IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Histone H3 pT3/R2Me2s was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with human Histone H3. A BLAST analysis was used to suggest cross-reactivity with Human, mouse, and C. elegans. Predicted to react with many species including rat, chicken, Xenopus, Drosophila, and plant based on 100% sequence homology. Cross-reactivity with Histone H3 from other sources has not been determined. Chromatin is the arrangement of DNA and proteins in which chromosomes are formed. Correspondingly, chromatin is formed from nucleosomes, which are comprised of a set of four histone proteins (H2A, H2B, H3, H4) wrapped with DNA. Chromatin is a very dynamic structure in which numerous post-translational modifications work together to activate or repress the availability of DNA to be copied, transcribed, or repaired. These marks decide which DNA will be open and commonly active (euchromatin) or tightly wound to prevent access and activation (heterochromatin). Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine. In particular phosphorylation of threonine 3 (H3 pT3) is a known mark of mitosis. Recent findings also demonstrate that pT3 can promote binding of survivin in the nucleosome. Arg2 may have opposing effects to pT3. Anti-Histone H3 pT3/R2Me2s is ideal for researchers Chromatin Modifiers, Chromatin Research, Histones and Modified Histones, and Epigenetics research. |
| Immunogen | Histone H3 pT3/R2Me2s affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide surrounding the pT3 and R2Me2s site of human Histone H3. |
| Other Names | rabbit anti-Histone H3 pT3 Sym-dimethyl Arg2 antibody, Histone H3 pT3 dimethyl R2s, Histone H3 pT3/R2Me2s, Histone H3 antibodies |
| Gene, Accession # | HIST2H3C, Gene ID: 126961, NCBI: NP_001005464.1, UniProt: Q71DI3 |
| Catalog # | 600-401-P14 |
| Price | $495 |
| Order / More Info | Histone H3 pT3/R2-Me2s Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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