MPYS Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | MPYS |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-MPYS Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with MPYS with Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with MPYS from other sources has not been determined. MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist. Anti-MYPS antibody is ideal for investigators involved transcription factor and infectious disease. |
| Immunogen | MPYS Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide near the c-terminus of human MPYS. |
| Other Names | MPYS, Transmembrane protein 173, TMEM173, ERIS, MITA, STING, Stimulator of interferon genes protein, hSTING, Mediator of IRF3 activation |
| Gene, Accession # | TMEM173, Gene ID: 340061, NCBI: NP_938023, UniProt: Q86WV6 |
| Catalog # | 600-401-C08 |
| Price | $475 |
| Order / More Info | MPYS Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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