IKAP Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | IKAP |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-IKAP Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with IKAP from other sources has not been determined. IKAP was initially identified as a scaffold protein of the IkB kinase complex that could bind to IKKa, IKKb, NF-kB, and the NF-kB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist. |
| Immunogen | Anti-IKAP antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the C-terminus of human IKAP. |
| Other Names | IKAP Antibody, FD, DYS, ELP1, IKI3, TOT1, Elongator complex protein 1, IkappaB kinase complex-associated protein, IKK complex-associated protein, p150 |
| Gene, Accession # | ELP1, Gene ID: 8518, NCBI: AAC64258, UniProt: O95163 |
| Catalog # | 600-401-BT8 |
| Price | $475 |
| Order / More Info | IKAP Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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