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Antigenic Specificity | IL-34 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 100 µg |
Concentration | 1.0 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-IL 34 is affinity chromatography purified via peptide column. The IL34 gene is conserved in chimpanzee, dog, cow, mouse, and rat. This antibody reacts with IL-34 from human, mouse, and rat sources. Reactivity with IL-34 from other sources has not been determined. Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages. Anti-IL-34 Antibody is ideal for investigators involved in Cell Signaling, Immunology and Signal Transduction research. |
Immunogen | Anti-IL-34 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human IL-34 protein. |
Other Names | IL-34, Interleukin-34 |
Gene, Accession # | IL34, Gene ID: 146433, NCBI: 187610438, UniProt: Q6ZMJ4 |
Catalog # | 600-401-C06 |
Price | $475 |
Order / More Info | IL-34 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |