HSPB2 (MKBP) Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | HSPB2 (MKBP) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-HSPB2 (MKBP) Antibody was purified by affinity chromatography. A BLAST analysis was used to suggest cross-reactivity with HSPB2 (MKBP) from Human, Mouse, and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with HSPB2 (MKBP) from other sources has not been determined. Heat Shock research. HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30% sequence identity to all other mammalian sHSPS. MKBP is known to associate specifically with myotonic dystrophy protein kinase (DMPK) in skeletal muscle. MKBP enhances the kinase activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique nature compared to other sHSps, in that the expression of MKBP is not induced by heat shock. In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction. During stress, these complexes dissolve and MKBP's localization to mitochondria increases, leading to increased cell survival. Pinz et al. tried to find a distinct role for MKBP in terms of cardiac mechanics and finds that it is required for normal systolic performance and normal cardiac energetic. HSPB2 has also been found to be expressed in several cancer cell lines, including human breast cancer, suggesting that MKBP may be an important factor in tumor transformation and metastasis. |
| Immunogen | HSPB2 Antibody was produced from whole rabbit serum prepared by repeated immunizations raised against a synthetic peptide. |
| Other Names | DMPK-binding protein, heat shock 27kDa protein 2, Hsp27, HspB2, MKBP, MGC133245, Heat shock protein beta-2 |
| Gene, Accession # | HSPB2, Gene ID: 3316, NCBI: NP_001532.1, UniProt: Q16082 |
| Catalog # | 600-401-F76 |
| Price | $445 |
| Order / More Info | HSPB2 (MKBP) Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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