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Antigenic Specificity | AP2M1 |
Clone | polyclonal |
Host Species | Chicken |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.0 mg/mL |
Applications | Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-AP2M1 Antibody is an IgY fraction that has been affinity purified by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with AP2M1 with Human, Rat and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with AP2M1 from other sources has not been determined. AP2M1 antibody detects human AP2M1. The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist. Anti-AP2M1 antibodies are ideal for investigators involved in infectious disease and enzyme research. |
Immunogen | AP2M1 Antibody was produced in chicken by repeated immunizations with a peptide near the c-terminus of human AP2M1. |
Other Names | CLAPM1, KIAA0109 |
Gene, Accession # | AP2M1, Gene ID: 1173, NCBI: NP_004059, UniProt: Q96CW1 |
Catalog # | 600-901-G75 |
Price | $475 |
Order / More Info | AP2M1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |