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Antigenic Specificity | Nephrin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Nephrin Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Nephrin from other sources has not been determined. Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm. |
Immunogen | Anti-Nephrin antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the internal region of human Nephrin. |
Other Names | Nephrin Antibody, CNF, NPHN, nephrin, Nephrin, Renal glomerulus-specific cell adhesion receptor |
Gene, Accession # | NPHS1, Gene ID: 4868, NCBI: NP_004637, UniProt: O60500 |
Catalog # | 600-401-CZ9 |
Price | $475 |
Order / More Info | Nephrin Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |