GFAP R416WT Antibody from ROCKLAND IMMUNOCHEMICALS INC.

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Antigenic SpecificityGFAP R416WT
CloneS206B-9
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
IsotypeIgG1
Formatperoxidase (HRP) conjugate
Size100 µg
Concentration1mg/mL
ApplicationsELISA, Immunohistochemistry, Western Blot
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DescriptionAnti-GFAP R416WT Antibody was purified from concentrated tissue culture supernate by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with rat and mouse based on 100% homology with the immunizing sequence. No cross-reactivity with other GFAP mutant proteins can be expected. The 50 kDa type III intermediate filament protein glial fibrillary acidic protein (GFAP) is a major structural component of astrocytes. GFAP associates with the calcium binding protein annexin II-p2 and S-100. Association with these proteins together with phosphorylation regulates GFAP polymerization. Astroycytes respond to brain injury by proliferatin (astrogliosis), and one of the first events to occur during astrocyte proliferation is increased GFAP expression. Interestingly, antibodies to GFAP have been detected in individuals with dementia. Anti-GFAP is ideal for investigators involved in Neuroscience Research, including Alexander Disease, Oligodendroglioma, Cytoskleton Remolding Neurofilaments and PIP3/AKT Signaling.
ImmunogenAnti-GFAP R416WT Antibody was produced in mice by repeated immunizations with a synthetic peptide corresponding to amino acids 411-422 (KTVEMRDGEVIK) of human GFAP.
Other NamesGlial fibrillary acidic protein, Intermediate filament protein, Astrocyte, gfapl, DKFZp459C0729, MGC139638, FLJ45472, AI836096, GFAP antibody
Gene, Accession #GFAP, Gene ID: 2670, UniProt: P14136
Catalog #200-303-W56
Price$495
Order / More InfoGFAP R416WT Antibody from ROCKLAND IMMUNOCHEMICALS INC.
Product Specific Referencesn/a
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654

orders@rockland.com
Technical Support: tech@rockland.com

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