Anthrax PA Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Anthrax PA |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | Bacillus sp. |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Anthrax PA Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Anthrax PA from other sources has not been determined. Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism. |
| Immunogen | Anti-Anthrax PA antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to 16 amino acids in the internal region of the Anthrax protective antigen protein. |
| Other Names | Anthrax PA Antibody , pag, pXO1-110, BXA0164, GBAA_pXO1_0164, Protective antigen, Anthrax toxins translocating protein, pxo1_110, Protective antigen PA-20, PA20, Protective antigen PA-63, PA63, Protective antigen, PA-83, PA83, Plasmid pXO1 |
| Gene, Accession # | pagA, Gene ID: 3361714, NCBI: AAF86457, UniProt: P13423 |
| Catalog # | 600-401-Y22 |
| Price | $475 |
| Order / More Info | Anthrax PA Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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