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Antigenic Specificity | IKK alpha |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-IKK alpha Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. This polyclonal antibody has no cross response to IKKb or IKKy. Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa and bacteria product LPS. NF-kB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. The long-sought IkB kinase (IKK), which phosphorylates IkB, and mediates IkB degradation and NF-kB activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKa and IKKb). IKKa and IKKb interact with each other and both are essential for the NF-kB activation. IKKa specifically phosphorylates IkB-alpha. IKKa is expressed in a variety of human tissues. |
Immunogen | Anti-IKK alpha antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid peptide near the C-terminus of human IKK alpha. |
Other Names | IKK alpha Antibody, IKK1, IKKA, IKBKA, TCF16, NFKBIKA, IKK-alpha, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase alpha |
Gene, Accession # | CHUK, Gene ID: 1147, NCBI: AF009225, UniProt: O15111 |
Catalog # | 600-401-BU0 |
Price | $475 |
Order / More Info | IKK alpha Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |