CAD Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | CAD |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-CAD Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with CAD from other sources has not been determined. Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death. |
| Immunogen | Anti-CAD antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid peptide near the C-terminus of murine CAD. |
| Other Names | DFF40 Antibody, CAD, CPAN, DFF2, DFF-40, Didff, 5730477D02Rik, Cad, DNA fragmentation factor subunit beta, CAD, Caspase-activated deoxyribonuclease, Caspase-activated DNase, Caspase-activated nuclease, DNA fragmentation factor 40 kDa subunit |
| Gene, Accession # | DFFB, Gene ID: 1677, NCBI: NP_001307061.1, UniProt: O76075 |
| Catalog # | 600-401-AA5 |
| Price | $475 |
| Order / More Info | CAD Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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