p19Arf Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | p19Arf |
| Clone | 12.A1.1 |
| Host Species | Rat |
| Reactive Species | human, mouse, hamster |
| Isotype | IgG2b |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This is a Protein G purified antibody directed against mouse p19Arf protein. No reactivity is observed against human or hamster homologues. The epitope was putatively mapped to amino acids 54-62 of mouse p19Arf. BLAST analysis indicates that no significant sequence homology exists for this sequence with p19Arf homologues from other sources. This epitope is also found on mouse p16Ink4a protein. No additional information is available for reactivity with p19Arf protein from other sources. The Ink4a-Arf locus encodes two tumor suppressor proteins, p16Ink4a and p19Arf. Expression of Ink4a and Arf is regulated by distinct promoters upstream of alternative first exons whose products are spliced to a common second exon translated in alternative reading frames (from which Arf gets its name). The two genes are induced by different stress signals and can be separately mutated or silenced in tumor cells. Targeted disruption of either or both genes in mouse leads to spontaneous tumor formation, which is accelerated by exposure of the mutant animals to chemical carcinogens or ionizing radiation. Inactivation of ARF by mutation, deletion, or epigenetic silencing is observed in many human cancers, underscoring the role of this protein as a potent and ubiquitous tumor suppressor. p19Arf is activated by Myc or mutant Ras. Once activated, p19Arf binds to the p53 negative regulator Mdm2, leading to p53 stabilization and unleashing a p53-dependent transcriptional program that triggers either cell cycle arrest or apoptosis. p19Arf also has p53-independent inhibitory effects on cell proliferation. p19Arf is a nucleolar protein and is implicated in ribosomal biogenesis. |
| Immunogen | This protein G purified monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues 54-75 of mouse p19Arf protein. |
| Other Names | rat anti-p19Arf Antibody, Cyclin-dependent kinase inhibitor 2A isoform 3, p19 ARF |
| Gene, Accession # | Cdkn2a, Gene ID: 12578, NCBI: 1162947, UniProt: Q64364 |
| Catalog # | 200-501-892 |
| Price | $485 |
| Order / More Info | p19Arf Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 16340309 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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