TEM1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | TEM1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-TEM1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least two isoforms of TEM1 are known to exist; this antibody recognizes both isoforms. Predicted species reactivity based on immunogen sequence: Mouse (86%); Rat: (86%). Tumor endothelial marker (TEM) 1 was originally identified as a human embryonic fibroblast-specific antigen and was later determined to be endosialin, a single-pass transmembrane glycoprotein that has multiple extracellular domains, including three EGF-like domains, a sushi-like domain, and a C lectin-like domain. TEM proteins are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. While TEM1 is not required for angiogenesis during fetal development, postnatal growth or wound healing, it plays a role in tumor growth, invasion, and metastasis. Fibronectin and collagen types I and IV act as specific ligands of TEM1, leading to suggestions that these molecules may cause changes in the extracellular matrix, cell adhesion and migration during tumor invasion. |
| Immunogen | Anti-TEM1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide near the C-terminus of the human TEM1. The immunogen is located within the last 50 amino acids of TEM-1. |
| Other Names | TEM1 Antibody, CD164L1, Endosialin, Tumor endothelial marker 1, CD248 |
| Gene, Accession # | CD248, Gene ID: 57124, NCBI: NP_065137.1, UniProt: Q9HCU0 |
| Catalog # | 600-401-FB7 |
| Price | $475 |
| Order / More Info | TEM1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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