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Antigenic Specificity | XEDAR |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-XEDAR Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with XEDAR from other sources has not been determined. X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment. |
Immunogen | Anti-XEDAR antibody was prepared from whole rabbit serum produced by repeated immunizations with recombinant human XEDAR. |
Other Names | XEDAR Antibody, XEDAR, EDAA2R, EDA-A2R, TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor |
Gene, Accession # | EDA2R, Gene ID: 60401, NCBI: NP_001186616.1, UniProt: Q9HAV5 |
Catalog # | 600-401-GA0 |
Price | $475 |
Order / More Info | XEDAR Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |