TBK1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | TBK1 |
| Clone | 108A429 |
| Host Species | Mouse |
| Reactive Species | human, mouse |
| Isotype | IgG1 kappa |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-TBK1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-TBK1 from Human, Mouse, cow, dog and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-TBK1 from other sources has not been determined. Anti-TBK1 NAK Antibody detects human TBK1 NAK. NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing it's translocation to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recently, a new IKK family member, TBK1 [(TANK-binding kinase), also known as NAK and T2K] has been identified. TANK (TRAF-associated NF-kB activator) interacts with TBK1 and activates NF-kB in a kinase dependent manner. Anti-TBK1 NAK Antibody is ideal for investigators involved in NFkappaB and apoptosis research. |
| Immunogen | TBK1 Antibody was produced in mice prepared by repeated immunizations with a synthetic peptide corresponding to internal amino acids of the human protein TBK1. |
| Other Names | NAK, Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1 |
| Gene, Accession # | TBK1, Gene ID: 29110, NCBI: NP_037386.1, UniProt: Q9UHD2 |
| Catalog # | 200-301-I22 |
| Price | $549 |
| Order / More Info | TBK1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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