Edit |   |
---|---|
Antigenic Specificity | RWDD3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-RWDD3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with RWDD3 from other sources has not been determined. RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases IkBeta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of IkBeta increased stability. RSUME-enhanced sumoylation of IkBeta leads to the inhibition of NF-kBeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis. |
Immunogen | Anti-RWDD3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the N-terminus of human RWDD3. |
Other Names | RWDD3 Antibody, RSUME, RSUME, RWD domain-containing protein 3, RWD-containing sumoylation enhancer |
Gene, Accession # | RWDD3, Gene ID: 25950, NCBI: NP_056300, UniProt: Q9Y3V2 |
Catalog # | 600-401-ED4 |
Price | $475 |
Order / More Info | RWDD3 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |