Damage Related Autophagy Modulator Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Damage Related Autophagy Modulator |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Flow Cytometry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This affinity purified antibody is directed against human DRAM protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with DRAM from human, mouse and rat sources. Reactivity with DRAM from other sources has not been determined. Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human DRAM protein. |
| Other Names | DRAM antibody, FLJ11259 antibody, DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator, DRAM1 |
| Gene, Accession # | DRAM1, Gene ID: 55332, NCBI: NP_060840.2, UniProt: Q8N682 |
| Catalog # | 600-401-A70 |
| Price | $475 |
| Order / More Info | Damage Related Autophagy Modulator Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 19736526 // 21771054 // 25308496 // 30990357 // 34096003 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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