DARPP-32 phospho S137 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | DARPP-32 phospho S137 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-DARPP-32 pS137 antibody is directed against DARPP-32 S137. Anti-DARPP-32 pS137 antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated DARPP-32 pS137. Minimal reactivity occurs against non-phosphorylated DARPP-32 pS137. Reactivity is completely blocked by treatment with lambda-phosphatase. Reactivity against DARPP-32 pS137 occurs from rat sources. However, reactivity is also expected against bovine, canine, human, mouse and NHP sources. DARPP-32 Antibody detects DARPP-32 which is a dopamine (DA) and cAMP-regulated ~32k phosphoprotein that is associated with dopaminoceptive neurons. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®. Serine 137 is phosphorylated by casein kinase 1 and phosphorylation of this site is increased following acute administration of Prozac®. Anti-DARPP-32 pS137 Antibody is ideal for investigators involved in Neuroscience and Cell Signaling Research. |
| Immunogen | Anti-DARPP-32 pS137 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser137 conjugated to KLH. |
| Other Names | Protein phosphatase 1 regulatory subunit 1B, Dopamine- and cAMP-regulated neuronal phosphoprotein |
| Gene, Accession # | Ppp1r1b, Gene ID: 360616, UniProt: Q6J4I0 |
| Catalog # | 612-401-D26 |
| Price | $475 |
| Order / More Info | DARPP-32 phospho S137 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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