SAP97 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | SAP97 |
| Clone | S64-15 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | Immunohistochemistry, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-SAP97 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with SAP97 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. No cross-reactivity against PSD95, SAP102 and Chapsyn110 expressed in transfected cells. Cross-reactivity with SAP97 from other sources has not been determined. Ion Channels research. Synapse-Associated Protein 97 (SAP97/human homologue of Drosophila discs-large tumor suppressor or HDLG) is one of a family of plasma membrane-associated proteins found in synaptic junctions. This is a novel, presynaptic membrane protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. SAP97 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP97 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and Shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between SAP97 and other proteins. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif (2). Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP97 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP97 in vitro through a pseudo-homotypic PDZ-PDZ interaction. |
| Immunogen | SAP97 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to an n-terminal region of rat SAP97. |
| Other Names | Dlgh1, SAP97, Dlg1, Synapse-associated protein 97, Disks large homolog 1 |
| Gene, Accession # | Dlg1, Gene ID: 25252, NCBI: NP_036920.1, UniProt: Q62696 |
| Catalog # | 200-301-G39 |
| Price | $485 |
| Order / More Info | SAP97 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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