SHOC2 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | SHOC2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-SHOC2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with SHOC2 from other sources has not been determined. SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair. |
| Immunogen | Anti-SHOC2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 21 amino acid synthetic peptide near the N-terminus of human SHOC2. |
| Other Names | SHOC2 Antibody, SOC2, SUR8, SIAA0862, KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog |
| Gene, Accession # | SHOC2, Gene ID: 8036, NCBI: NP_031399, UniProt: Q9UQ13 |
| Catalog # | 600-401-EJ4 |
| Price | $475 |
| Order / More Info | SHOC2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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