TAP1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | TAP1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | ion exchange purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This product was prepared from monospecific antiserum by delipidation, salt fractionation and ion exchange chromatography. A single precipitin arc was observed against anti-Rabbit Serum when assayed by immunoelectrophoresis. TAP1 (Transporter 1, ATP Binding Cassette Subfamily B Member) Members of the MDR/TAP subfamily are involved in multidrug resistance. TAP1 is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. It also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. It is inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, celiac disease, Bare Lymphocyte Syndrome, Type I and Immunodeficiency by Defective Expression Of Hla Class 1. Anti-TAP1 Antibody is ideal for researchers interested in the Innate Immune System and Class I MHC. |
| Immunogen | Transporter Associated Protein (TAP I ) peptide corresponding to the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH). |
| Other Names | rabbit anti-TAP1 antibody, rabbit anti-ABCB2 antibody, TAP 1 antibody, PSF1 antibody, RING4 antibody, TAP1N antibody, Antigen peptide transporter 1, ATP-binding cassette sub-family B member 2, Transporter 1 ATP binding cassette sub family B (MDR/TAP) antibody |
| Gene, Accession # | TAP1, Gene ID: 6890, NCBI: AAS55412.1, UniProt: Q03518 |
| Catalog # | 200-401-102 |
| Price | $475 |
| Order / More Info | TAP1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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