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Antigenic Specificity | PDL1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.0 mg/mL |
Applications | ELISA, Flow Cytometry, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-PDL-1 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with PD-L1 with Human, Rat, and Mouse based on 100% homology with the immunizing sequence. PDL-1 antibody has no cross-reactivity to PDL-2. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger isoform. Cross-reactivity with PDL-1 from other sources has not been determined. Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PDCD-1 (Programmed Cell Death 1) that mediate inhibitory signals from the APC. PDCD-1 can bind two different but related ligands, PDL-1 and PDL-2 (Programmed Cell Death Ligand -1 and -2, respectively). PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. Anti-PDL-1 antibody is ideal for investigators involved in cancer research, cytokine research, immune research and apoptosis research. |
Immunogen | PDL-1 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to an internal region of human PDL-1. |
Other Names | Rabbit anti-PDL1 antibody, Rabbit Anti-Programmed cell death 1 ligand 1 Antibody, Programmed cell death ligand 1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, PD-L1, PDCD1 ligand 1, B7-H1, B7 homolog 1, PDL-1, PDL 1 |
Gene, Accession # | CD274, Gene ID: 29126, NCBI: Q9NZQ7.1, UniProt: Q9NZQ7 |
Catalog # | 600-401-A71 |
Price | $475 |
Order / More Info | PDL1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |