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Antigenic Specificity | IL-17 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-IL-17 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with IL-17 from other sources has not been determined. Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-kB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
Immunogen | Anti-IL-17 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the N-terminus of human IL-17A. |
Other Names | IL-17 Antibody, IL17, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8 |
Gene, Accession # | IL17A, Gene ID: 3605, NCBI: NP_002181, UniProt: Q16552 |
Catalog # | 600-401-BU7 |
Price | $475 |
Order / More Info | IL-17 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |