NMDA R1, Splice Variant N1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | NMDA R1, Splice Variant N1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 25 µg |
| Concentration | n/a |
| Applications | Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-NMDA R1, Splice Variant N1 antibody is directed against NMDA R1 protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. This antibody does not recognize NR1 subunits of the NMDA receptor that do not contain the N1 insert. Reactivity is expected from the following species based on 100% sequence homology: canine, chicken, human, non-human primates and Xenopus. NMDA R1, Splice Variant N1 Antibody detects NMDA R1 protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA Receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. There are a number of different splice variants of the NR1-Subunit. Differential splicing of three exons in the NR1-Subunit generates up to eight NR1-Subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR. Anti-NMDA R1, Splice Variant N1 Antibody is ideal for investigators involved in Neuroscience and Signal Transduction research. |
| Immunogen | Anti-NMDA NR1 Subunit, Splice Variant N1 Antibody was produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues specific to the NR1 subunit, N1 splice variant insert. |
| Other Names | Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1, NMD-R1, Grin1 |
| Gene, Accession # | Grin1, Gene ID: 24408, NCBI: NP_058706.1, UniProt: P35439 |
| Catalog # | 600-401-D88 |
| Price | $475 |
| Order / More Info | NMDA R1, Splice Variant N1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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