ATF2 phospho S490/phospho S498 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | ATF2 phospho S490/phospho S498 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | ELISA, Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-ATF2 pS490/pS498 Antibody is directed against ATF2 protein phosphorylated at S490/pS498. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated ATF2. Minimal reactivity occurs against non-phosphorylated ATF2. Reactivity against ATF2 occurs from human sources. However, reactivity is also expected against rat based on 100% sequence homology. ATF2 antibody recognizes the activating transcription factor ATF2 (also called CRE-BP1) which binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF2 has been implicated in the transcriptional regulation of a number of genes including cytokines, cell cycle control and apoptosis. Various forms of cellular stress, including inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF2. Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF. Serine 490 and serine 498 are novel phosphorylation sites on ATF that have recently been identified. ATF2 is particularly abundant in the brain and the ATF2 family of transcription factors is considered an important substrate of signals upstream of the activation of genes associated with neuronal growth and differentiation. ATF expression has also been linked to the depression in humans. Anti-ATF2 pS490/pS498 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research. |
| Immunogen | Anti-ATF2 pS490/pS498 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser490/498. |
| Other Names | rabbit anti-ATF2 pS490/pS498 Antibody, Cyclic AMP-dependent transcription factor ATF-2, Activating transcription factor 2, Cyclic AMP-responsive element-binding protein 2, CREB-2, HB16, cAMP response element-binding protein CRE-BP1 |
| Gene, Accession # | ATF2, Gene ID: 1386, NCBI: AAI07699.1, UniProt: P15336 |
| Catalog # | 609-401-D11 |
| Price | $475 |
| Order / More Info | ATF2 phospho S490/phospho S498 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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