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Antigenic Specificity | Precerebellin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.0 mg/ml |
Applications | ELISA, Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Precerebellin Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Precerebellin from other sources has not been determined. Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin possesses functions other than those already stated. |
Immunogen | Anti-Precerebellin antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from the internal region of human precerebellin. |
Other Names | Precerebellin Antibody, Cerebellin-1, Precerebellin, CER |
Gene, Accession # | CBLN1, Gene ID: 869, NCBI: P23435, UniProt: P23435 |
Catalog # | 600-401-DS6 |
Price | $475 |
Order / More Info | Precerebellin Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |