HSP22 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | HSP22 |
| Clone | 3C12-H11 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 kappa |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1mg/mL |
| Applications | ELISA, Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Hsp22 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Hsp22 from human, mouse, and rat based on 100% homology with the immunizing sequence. Detects endogenous and exogenous hsp22 in monomeric, dimeric and tetrameric forms in WB. Does not cross react with alpha crystallin. Cross-reactivity with Hsp22 from other sources has not been determined. Heat Shock research. Hsp22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta. Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27. HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs (3). The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macroautophagy. Mutations in the HSPB8 gene are associated with the inherited peripheral neurpathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L). |
| Immunogen | Hsp22 Antibody was produced in mice by repeated immunizations raised against a his-tagged human recombinant hsp22. |
| Other Names | Alpha crystallin C chain, CMT2L, CRYAC, DHMN2, H11, Heat shock 22kDa protein 8, HMN2, HSB8, HspB8, Heat shock protein beta-8, E2IG1, HSP22, E2-induced gene 1 protein, Protein kinase H11 |
| Gene, Accession # | HSPB8, Gene ID: 26353, NCBI: NP_055180.1, UniProt: Q9UJY1 |
| Catalog # | 200-301-F53 |
| Price | $485 |
| Order / More Info | HSP22 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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