Hsp70 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Hsp70 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat, anthozoa, atlantic hagfish, beluga, bovine, carp, dog, guinea pig, hamster, monkey, porcine, sheep, spiny dogfish, tobacco, tomato |
| Isotype | n/a |
| Format | serum |
| Size | 100 µL |
| Concentration | 85 mg/mL |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Hsp70 Antibody was prepared from monospecific antiserum by delipidation and defibrination. A BLAST analysis was used to suggest cross-reactivity with Hsp70 from Human, mouse, rat, beluga, cow, dog, fish (carp), guinea pig, hamster, monkey, pig, sheep, coral, tomato, tobacco, spiny dogfish shark (Squalus acanthias), and Atlantic Hagfish (Myxine glutinosa) based on 100% homology with the immunizing sequence. Cross-reactivity with Hsp70 from other sources has not been determined. Heat Shock research. Hsp70 genes encode abundant heat-inducible 70-kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity. The N-terminal two thirds of hsp70s are more conserved than the C-terminal third. Hsp70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides. When hsc70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half. The structure of this ATP binding domain displays multiple features of nucleotide binding proteins. When cells are subjected to metabolic stress (e.g., heat shock) a member of the hsp 70 family, hsp 70 (hsp72), is expressed; hsp 70 is highly related to hsc70 (>90% sequence identity). Constitutively expressed hsc70 rapidly forms a stable complex with the highly inducible hsp70 in cells following heat shock. The interaction of hsc70 with hsp 70 is regulated by ATP. These two heat shock proteins move together in the cell experiencing stress. Furthermore, research on hsc70 has implicates it with a role in facilitating the recovery of centrosomal structure and function after heat shock. |
| Immunogen | Hsp70 Antibody was produced from whole rabbit serum prepared by repeated immunizations raised against full length protein Hsp70. |
| Other Names | Hsp70 1, Hsp70 2, Hsp70.1, Hsp72, Hsp73, HSPA1, HSPA1A, HSPA1B, Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2 |
| Gene, Accession # | HSPA1A, Gene ID: 3303, NCBI: NP_005336.3, UniProt: P08107 |
| Catalog # | 100-401-F63 |
| Price | $445 |
| Order / More Info | Hsp70 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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