MARCH8 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | MARCH8 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-MARCH8 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with MARCH8 from other sources has not been determined. MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation. |
| Immunogen | Anti-MARCH8 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the C-terminus of human MARCH8. |
| Other Names | MARCH8 Antibody, MIR, c-MIR, RNF178, MARCH-VIII, MIR, E3 ubiquitin-protein ligase MARCH8, Cellular modulator of immune recognition |
| Gene, Accession # | MARCH8, Gene ID: 220972, NCBI: NP_659458, UniProt: Q5T0T0 |
| Catalog # | 600-401-CQ9 |
| Price | $475 |
| Order / More Info | MARCH8 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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