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Antigenic Specificity | IRF4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.0 mg/ml |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-IRF4 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. IRF4 antibody is predicted to not cross-react with other IRF protein family members. IRF4 often migrates at a higher than predicted molecular weight in SDS-PAGE. Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Another member, IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF4 expression is tightly regulated in resting primary T cells and plays an essential role in the homeostasis and function of mature lymphocytes. IRF4 is induced by Toll-like receptor (TLR) activation and acts as a negative regulator of TLR signaling. |
Immunogen | Anti-IRF4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the C-terminus of human IRF4. |
Other Names | IRF4 Antibody, MUM1, LSIRF, NF-EM5, MUM1, Interferon regulatory factor 4, Lymphocyte-specific interferon regulatory factor, IRF-4 |
Gene, Accession # | IRF4, Gene ID: 3662, NCBI: NP_002451, UniProt: Q15306 |
Catalog # | 600-401-CA3 |
Price | $475 |
Order / More Info | IRF4 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |