p38 alpha MAPKinase Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | p38 alpha MAPKinase |
| Clone | 9F12 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti- p38 α MAP Kinase Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest no known cross-reactivity with other related human kinases. Cross-reactivity with p38α MAP kinase from other sources has not been determined. Cell Signaling research. The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmentalchanges in organisms. This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway. The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP. p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeuticdrugs. As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes. |
| Immunogen | p38 Antibody was produced in mice by repeated immunizations raised against a full length recombinant protein expressed in E.coli cells. |
| Other Names | CSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A, Mitogen-activated protein kinase 14, Cytokine suppressive anti-inflammatory drug-binding protein |
| Gene, Accession # | MARK14, Gene ID: 1432, NCBI: NP_001306.1, UniProt: Q16539 |
| Catalog # | 200-301-G27 |
| Price | $485 |
| Order / More Info | p38 alpha MAPKinase Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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