TNFAIP3 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | TNFAIP3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-TNFAIP3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with TNFAIP3 from other sources has not been determined. TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kB-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist. |
| Immunogen | Anti-TNFAIP3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide near the C-terminus of human TNFAIP3. |
| Other Names | TNFAIP3 Antibody, A20, Tnfip3, Tumor necrosis factor alpha-induced protein 3, Putative DNA-binding protein A20, TNF alpha-induced protein 3 |
| Gene, Accession # | TNFAIP3, Gene ID: 7128, NCBI: NP_001257436.1, UniProt: P21580 |
| Catalog # | 600-401-FK7 |
| Price | $475 |
| Order / More Info | TNFAIP3 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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