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Antigenic Specificity | Tetanus Toxic Fragment C |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | Clostridium tetani |
Isotype | n/a |
Format | serum |
Size | 100 µL |
Concentration | 90 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is directed against the C fragment of Tetanus toxin derived from Clostridium tetani. The product was prepared from monospecific antiserum by delipidation and defibrination. A BLAST analysis was used to suggest cross reactivity with Clostridium tetani. Cross-reactivity with TTFC from other sources have not been determined. Tetanus toxin C-fragment (TTc) is a non-toxic 52 kD polypeptide generated by papain cleavage of tetanus toxin, corresponding to the C-terminal 451 amino acids. The illness known as Tetanus is caused by a neurotoxin produced by the anaerobic bacterium Clostridium tetani. C. tetani is commonly found in soil, feces, and on many objects lying on the ground, such as rusty metal, hence puncture wounds are a common cause of tetanus. It acts upon the presynaptic membranes of both central and peripheral nervous systems to block the release of neurotransmitters. In its toxic form tetanus neurotoxin is a 150 kDa protein, consisting of two major components: a light chain and heavy chain. The light chain contains the enzymatic portion of the toxin and is responsible for its toxic effects. The heavy chain binds to the neuron and aids delivery of the light chain to the neuron interior. A single disulfide bond links light and heavy chains. |
Immunogen | This antibody was prepared from whole rabbit serum produced by repeated immunizations with a polyhistidine-tagged TTFC fusion protein expressed in E. coli corresponding to full length TTFC. |
Other Names | rabbit anti-Tetanus Toxin Fragment C Antibody , TTfC, tentoxylysin, tetX |
Gene, Accession # | tetX, Gene ID: 1061100, NCBI: NP_783831.1, UniProt: P04958 |
Catalog # | 100-401-894 |
Price | $475 |
Order / More Info | Tetanus Toxic Fragment C Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | PubMed: 19465006 |