SIGIRR Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | SIGIRR |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1.0 mg/ml |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-SIGIRR Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with SIGIRR from other sources has not been determined. SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion. |
| Immunogen | Anti-SIGIRR antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. |
| Other Names | SIGIRR Antibody, TIR8, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, TIR8 |
| Gene, Accession # | SIGIRR, Gene ID: 59307, NCBI: CAG33619, UniProt: Q6IA17 |
| Catalog # | 600-401-EK1 |
| Price | $475 |
| Order / More Info | SIGIRR Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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