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Antigenic Specificity | FNIP2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.0 mg/ml |
Applications | ELISA, Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-FNIP2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1. FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. |
Immunogen | Anti-FNIP2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the C-terminus of human FNIP2. |
Other Names | FNIP2 Antibody, FNIPL, MAPO1, FNIPL, KIAA1450, Folliculin-interacting protein 2, FNIP1-like protein |
Gene, Accession # | FNIP2, Gene ID: 57600, NCBI: NP_065891, UniProt: Q9P278 |
Catalog # | 600-401-BF8 |
Price | $475 |
Order / More Info | FNIP2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |