Edit |   |
Antigenic Specificity | LIN28 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Lin28 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Lin28 from other sources has not been determined. Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. |
Immunogen | Anti-Lin28 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the C-terminus of human Lin28. |
Other Names | Lin28 Antibody, CSDD1, LIN28, LIN-28, ZCCHC1, lin-28A, CSDD1, Protein lin-28 homolog A, Zinc finger CCHC domain-containing protein 1, Lin-28A |
Gene, Accession # | LIN28A, Gene ID: 79727, NCBI: NP_078950, UniProt: Q9H9Z2 |
Catalog # | 600-401-CK9 |
Price | $475 |
Order / More Info | LIN28 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |