IKB alpha Ser32 Ser36 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | IKB alpha Ser32 Ser36 |
| Clone | 39A1413 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-IkBα Ser32 Ser36 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-IkBα Ser32 Ser36 from Bovine, Dog, Human, Mouse, Pig and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-IkBα Ser32 Ser36 from other sources has not been determined. Anti-IkBa Ser32 Ser36 Antibody detects human IkBa. NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. External stimuli such as tumor necrosis factor or other cytokines initiates a signal transduction cascade that leads to the activation of IkB-kinase complex that specifically phosphorylates IkBa on Serine-32 and Serine-36. Phosphorylation of these sites leads to ubiquitination of IkBa and subsequent degradation by the 26 S proteasome. Degradation of IkBa results in unmasking of the nuclear localization signal of NF-kB dimers, which subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first gene induced following NF-kB activation is IkBa. Anti-IkBa Ser32 Ser36 Antibody is ideal for investigators involved in NFkappaB, kinase and phosphatase research. |
| Immunogen | IkB alpha Ser32 Ser36 Antibody was produced in mice prepared by repeated immunizations with a synthetic peptide containing phosphorylated serines at human IkBa 32 and 36. |
| Other Names | IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3 |
| Gene, Accession # | NFKBIA, Gene ID: 4792, NCBI: NP_065390.1, UniProt: P25963 |
| Catalog # | 200-301-H81 |
| Price | $569 |
| Order / More Info | IKB alpha Ser32 Ser36 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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