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Antigenic Specificity | NIBRIN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-NIBRIN Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Two alternatively spliced transcript isoforms of NIBRIN are known to exist. NIBRIN (NBN) is a member of the double-strand break repair complex MRE11/RAD50/NBN (MRN) which is involved in DNA double-strand break repair, DNA damage-induced checkpoint activation and plays a critical role in the maintenance of chromosome integrity. NIBRIN contains two modules found in cell cycle checkpoint proteins, a forkhead-associated domain adjacent to a breast cancer carboxy-terminal domain. Mutations in this gene are associated with Nijmegen breakage syndrome and maybe the cause of cancer predisposition and aplastic anemia. |
Immunogen | Anti-NIBRIN antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the C-terminus of human NIBRIN. |
Other Names | NIBRIN Antibody, ATV, NBS, P95, NBS1, AT-V1, AT-V2, Nibrin, Cell cycle regulatory protein p95 |
Gene, Accession # | NBN, Gene ID: 4683, NCBI: NP_002476, UniProt: O60934 |
Catalog # | 600-401-DA9 |
Price | $475 |
Order / More Info | NIBRIN Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |