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Antigenic Specificity | FEZ1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-FEZ1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with FEZ1 from other sources has not been determined. Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist. |
Immunogen | Anti-FEZ1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide from near the C-terminus of human FEZ1. |
Other Names | FEZ1 Antibody, Fasciculation and elongation protein zeta-1, Zygin I |
Gene, Accession # | FEZ1, Gene ID: 9638, NCBI: NP_005094.1, UniProt: Q99689 |
Catalog # | 600-401-BE1 |
Price | $475 |
Order / More Info | FEZ1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |