Olig2 Phospho S10/13/14 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Olig2 Phospho S10/13/14 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified, no preservative |
| Size | 100 µL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Phospho-Ser10,13,14 Olig2 Antibody is directed against human Olig 2 protein phosphorylated at S10/13/14. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated Olig2. Minimal reactivity occurs against non-phosphorylated Olig2. Reactivity against Olig2 occurs from mouse sources. However, reactivity is also expected against guinea pig, human, non-human primate, mouse, rat and zebrafish based on 100% sequence homology. Olig2 is a well conserved bHLH transcription factor that shows both anti-neural functions and pro-neural functions at different stages in the formation of the oligodendrocyte lineage. Olig2 is expressed in 100% of the human diffuse gliomas irrespective of grade and required for intracranial tumor formation in a genetically relevant model of malignant glioma. A developmentally regulated triple serine motif at positions 10, 13 and 14 in the amino terminus is well conserved across species ranging from humans to zebrafish and is essential for Olig2 proliferative function in both normal and malignant neural progenitors. All three serine residues must be mutated to achieve a strong loss-of-function or gain-of-function phenotype, suggesting that the phosphorylation state of Olig2 represents a significant conformational change in the amino terminus. Olig2 pS 10/13/14 Antibody is ideal for researchers interested in neuroscience research. |
| Immunogen | Anti-Phospho-Ser10,13,14 Olig2 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser10,13,14 of human Olig2 conjugated to KLH. |
| Other Names | Oligodendrocyte transcription factor 2, Oligo2, Class B basic helix-loop-helix protein 1, bHLHb1, Class E basic helix-loop-helix protein 19, bHLHb19, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17 |
| Gene, Accession # | OLIG2, Gene ID: 10215, NCBI: NP_005797.1, UniProt: Q13516 |
| Catalog # | 600-401-X18 |
| Price | $475 |
| Order / More Info | Olig2 Phospho S10/13/14 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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