NMDA R2B phospho Y1252 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | NMDA R2B phospho Y1252 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-NMDA R2B pY1252 antibody is directed against rat NMDA R2B protein. NMDA R2B pY1252 antibody was affinity purified from monospecific antiserum by immunoaffinity purification. The antibody is specific for the phosphorylated NMDA R2B protein. Immunolabeling of the NMDA NR2B subunit band is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Immunolabeling is also blocked by lambda-phosphatase treatment. The antibody may also show some slight reactivity with Tyr1246 of NR2A. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, chicken, human, mouse, non-human primate and zebra fish. NMDA R2B pY1252 Antibody detects NMDA R2B protein. The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Phosphorylation of Tyr1252 is thought to potentiate NMDA receptor-dependent influx of calcium. Anti-NMDA R2B pY1252 Antibody is ideal for investigators involved in Neuroscience, Signal Transduction, and Cell Signaling Research. |
| Immunogen | Anti-NMDA R2B pY1252 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1252. |
| Other Names | Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, Grin2b |
| Gene, Accession # | Grin2b, Gene ID: 24410, UniProt: Q00960 |
| Catalog # | 612-401-D92 |
| Price | $475 |
| Order / More Info | NMDA R2B phospho Y1252 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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