IKK beta Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | IKK beta |
| Clone | 10A9B6 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 0.5 mg/mL |
| Applications | Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-IKKβ Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-IKKβ from Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-IKKβ from other sources has not been determined. Anti-IKKb IKK2 Antibody detects human IKKb IKK2. NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/alpha, IKK2/beta, and IKK3/gamma. IKK1/alpha and IKK beta are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recent studies have shown that IKK beta, not IKK1/alpha, is the target proinflammatory stimuli. Targeted disruption of IKK beta gene in mice also results in extensive liver damage from apoptosis and death as embryo. Anti-IKKb IKK2 Antibody is ideal for investigators involved in kinase and growth factor research. |
| Immunogen | IKK beta Antibody was produced in mice prepared by repeated immunizations with IKK beta, recombinant human protein. |
| Other Names | IKKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, 2.7.11.10, I-kappa-B kinase , IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB |
| Gene, Accession # | IKBKB, Gene ID: 3551, NCBI: NP_001177649.1, UniProt: O14920 |
| Catalog # | 200-301-H84 |
| Price | $525 |
| Order / More Info | IKK beta Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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