Caspase-12 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Caspase-12 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Caspase-12 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Caspase-12 from other sources has not been determined. Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues. |
| Immunogen | Anti-Caspase-12 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid peptide near the internal region of murine Caspase-12. |
| Other Names | Caspase-12 Antibody, Caspase-12, CASP-12 |
| Gene, Accession # | Casp12, Gene ID: 12364, NCBI: CAA73532, UniProt: O08736 |
| Catalog # | 600-401-AC7 |
| Price | $475 |
| Order / More Info | Caspase-12 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.