CD74 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | CD74 |
| Clone | PIN.1 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG |
| Format | purified |
| Size | 100 µg |
| Concentration | 1mg/mL |
| Applications | Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-CD74 Antibody was immunoglobulin purified. This monoclonal antibody is specific for human CD74. A BLAST analysis was used to suggest cross-reactivity with CD74 from human based on 100% homology with the immunizing sequence. Cross-reactivity with CD97 from other sources has not been determined. Cell Signaling research. CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal cytoplasmic tail of 28 amino acids, followed by a single 24-aa transmembrane region and an approximately 150-aa lumenal domain. The CD74 chain is thought to function mainly as an MHC class II chaperone, which promotes ER exit of MHC class II molecules, directs them to endocytic compartments, prevents peptide binding in the ER, and contributes to peptide editing in the MHC class II compartment. Class II MHC and Ii expression was believed to be restricted to classical antigen-presenting cells (APC); however, during inflammation, other cell types, including mucosal epithelial cells, have also been reported to express class II MHC molecules. Experiments that investigate cell-surface CD74 are complicated by the fact that CD74 remains on the cell surface for a very short time. The surface half-life of CD74 was calculated to be fewer than 10 minutes (3). CD74 however has also recently been shown to have a role as an accessory-signaling molecule because of its high-affinity binding to the pro-inflammatory cytokine, macrophage migration-inhibitory factor (MIF). The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. |
| Immunogen | CD74 Antibody was produced in mice by repeated immunizations with a human CD74 invariant chain synthetic peptide. |
| Other Names | mouse anti-CD74 antibody, mouse anti-Cluster of Differentiation 74 antibody, DHLAG, HLA DR gamma, HLADG, p33, p35, Protein 41 antibody, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain |
| Gene, Accession # | CD74, Gene ID: 972, NCBI: NP_001020329.1, UniProt: P04233 |
| Catalog # | 209-301-F12 |
| Price | $485 |
| Order / More Info | CD74 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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