NEUROMAB Profile

is an NIH-funded national monoclonal antibody-generating resource.
uses a unique neuroscience-based approach to generating mouse monoclonal antibodies optimized for use in mammalian brain (NeuroMabs).
performs comprehensive biochemical and immunohistochemical analyses of human, primate and non-primate mammalian brain in our initial screening procedure.
optimizes NeuroMabs for use in brain for immunocytochemical-based imaging studies of protein localization in adult, developing and pathological brain samples, for biochemical analyses of subunit composition and post-translational modifications of native brain proteins, and for proteomic analyses of native brain protein networks.
has made more than 320 NeuroMabs against neuronal membrane proteins (receptors/channels/transporters), synaptic proteins, other neuronal signaling molecules, and proteins with established links to disease states, neurodevelopmental targets, epigenetics targets and rare disease targets.
makes NeuroMabs available to the neuroscience research community on an inexpensive, non-profit basis as tissue culture supernatants or purified immunoglobulin.

Because we are fully NIH funded, there is no charge for this service.
Requestors should supply the UC Davis/NIH NeuroMab Facility with:
- a scientific justification as to the biological importance of the target molecule
- the importance of these reagents to the national neuroscience community
- the availability and suitability of existing polyclonal and/or monoclonal antibodies.
- a list of reagents (synthetic peptides, fusions proteins, full-length cDNAs for transfection in mammalian cells, samples from knockout mice) that will be made available to the UC Davis/NIH NeuroMab Facility staff to facilitate the development and characterization of these NeuroMabs.
Requests will be prioritized by our Scientific Advisory Board and NIH Program Officials.